Analysis and comparison of drugs for liver diseases in dogs

Analysis and comparison of drugs for liver diseases in dogs


Ingredients: S-adenosylmethionine (SAMA)

Nutramax USA

Dosage: 20mg/kg/d

1. Role

1.1 Transmethylation: It is involved in the synthesis of phospholipids and is very important for the structure, fluidity and function of cell membranes.

1.2 Transsulfation: It is the precursor of glutathione, synthesizes glutathione, and glutathione is a powerful antioxidant, which participates in many metabolisms of the body and liver detoxification, and is an important

1.3 Transaminopropyl effect: Aminopropyl plays an important role in the production of anti-inflammatory substances, the production of protein and DNA, the promotion of cell replication, and the renewal of liver tissue.

1.4 SAMe has the functions of anti-inflammatory, pain relief and tissue repair, and has a significant effect on arthropathy, and has the effect of significantly promoting cartilage formation and reducing joint pain, stiffness and swelling.

2. Usage

This product is an enteric-coated film-coated tablet. It must be taken completely on an empty stomach, 1 tablet in the morning and 1 tablet in the evening, 1 hour before or 4 hours after eating. It must not be broken, broken, chewed, or eaten.

In order to prevent food refusal from feeding the drug, you can wrap it with a small amount of soft food; if you take it with food, please take twice the amount.

It is the first choice for American veterinarians to treat various liver diseases in dogs and cats. Its main functions are to repair damaged liver cells, eliminate ascites, normalize biliary function, reduce jaundice, and promote active feeding in dogs and cats.

Second, Denamarin Liver Protection Enhancement Tablets 90 and Liver Protection Enhancement Tablets 225mg Chewable Tablets

Ingredients: s-adenosylmethionine, silymarin

Nutramax USA

1 role

1.1 Hepatoprotective effect: It has a strong antioxidant function, protects liver cells from free radical damage, captures free radicals, is far more effective than vitamin E, and strengthens the detoxification function of the liver.

1.2 Prevent liver cirrhosis and hepatitis, increase bile flow, and promote digestion and absorption of intestinal nutrients.

1.3 Promote protein synthesis, speed up the production of new liver cells, or make damaged liver cells repair themselves and increase glutathione levels.

1.4 Anti-tumor effect: Various reactive oxygen species can oxidize guanine to form 8-anthylguanine, which can cause DNA damage and then cause tumors. The application of antioxidants, especially free radical scavengers, can prevent the occurrence of this process.

2. Usage

2.1 Take it on an empty stomach (at least 1h before or 4h after meals).

2.2 Hepatoprotection Enhancement Tablets 90mg: sugar-coated tablet to protect it from gastric acid damage.

2.3 Liver-protection strengthening tablet 225mg chewable tablet: It can be divided, and it is not easy to be oxidized by embedding technology.

2.4 The added ingredient silymarin may have gastrointestinal reactions (vomiting or diarrhea).

Three, Zentonil

Ingredients: S-adenosylmethionine, lecithin

Zentonil, France

1. Role

Lecithin is known as the "third nutrient" alongside protein and vitamins.

2. Usage

Because its main ingredient is S-adenosylmethionine, it must also be taken on an empty stomach.


1. Composition and function

Analysis and comparison of medication for liver disease in dogs and cats

2. Usage

Recommended dosage: One tablet per 5 kg of body weight per day during the health care period, and the dose can be adjusted 2-3 times according to the situation.

Applicable to: Liver health care when liver index rises, acute or chronic hepatitis, poisoning, fatty liver and other liver damage, chronic disease long-term drug treatment.

Note: There is less or no silymarin in the conventional SAMe hepatoprotective drugs, (the adjuvant dose of silymarin in liver disease is 20-50mg/kg/d) Fengzgan can provide vitamin B group (SAMe is converted into glutathione)

V. Heparin

Ingredients: Taurine, L-Carnitine, Vitamin E, Coenzyme Q10, Essential Fatty Acids (DHA and EPA)


1. Role

1.1 Taurine: an essential amino acid for cats.

1.2 L-carnitine: to maintain normal nutrition and fat metabolism, it is an essential amino acid for the heart muscle, liver and nerve. It can enhance myocardial energy, improve myocardial contractility, and maintain the normal function of the heart.

1.3 Vitamin E: antioxidant, inhibits myocardial damage caused by free radicals and delays myocardial failure.

1.4 Coenzyme Q10: Improve myocardial function, lower cholesterol, lower blood pressure.

2. Treatment

2.1 Heart aspect: improve the cardiac contractility of animals, treat dilated heart disease, improve cardiac insufficiency, protect blood vessels, and prevent thrombosis.

2.2 Liver: mainly for fatty liver, cholestasis, promote bile secretion, and then improve liver function.

2.3 Other aspects: lower cholesterol, enhance immunity, strengthen muscles.

3. Dosage and usage: Below 10kg, 2 times a day, 1 tablet each time.

Six. Liver Tailor glucuronide

1. Function

Pharmacological effects: After entering the body, this product can be combined with toxic substances containing hydroxyl or carboxyl groups to form low-toxic or non-toxic conjugates that are excreted in urine, protecting the liver and detoxifying.

After the drug enters the body, the lactone ring is opened under the catalysis of the enzyme and converted into glucuronic acid, which is one of the important detoxification substances in the body.

2. Note:

The application of hepatic Tailor in cats is basically ineffective, but it will increase the metabolic burden of the liver.

Canine can be used for acute and chronic hepatitis, food or drug toxic hepatitis for liver protection and detoxification adjuvant therapy.

3. Dosage: 50-200mg/time for dogs, orally, 2-3 times a day.

100-200mg/time, intramuscularly or intravenously, once a day.

7. Liver Protection Capsules

1.Ingredients: Bupleurum, Cyperus officinalis, Turmeric, Angelica, Atractylodes, Schisandra, Astragalus, White Peony, Poria, Yinchen Penny, Banlangen, Licorice, etc.

2. Functions: Soothes the liver and regulates qi, clears heat and dissipates stagnation, softens the liver and strengthens the spleen, regulates qi and blood, reduces transaminase, and is used for acute and chronic hepatitis and early cirrhosis.

3. Dosage: 1 capsule per 10kg, 2 times a day, one month is a course of treatment.

8. Liver and Shenkang

1.Ingredients: Chuanqiong, Astragalus and other natural plant extracts.

2. Actions: It has the functions of clearing away heat and detoxifying, protecting liver and kidney, improving immunity, dispelling water and dissipating stagnation, diverting dampness, warming intestines and astringing lungs.

3. Dosage: Oral or drink, 1ml/kg, once a day for 3-5 days.

Summary of Oral Drugs

Analysis and comparison of drugs for liver diseases in dogs

Analysis and comparison of medication for liver disease in dogs and cats

Nine, liver complex peptide

This strain is a small molecule polypeptide active substance extracted and purified from fresh suckling pig liver, which has the following biological effects:

1. It can significantly stimulate the DNA synthesis of new hepatocytes, promote the recovery of damaged hepatocyte mitochondria and rough endoplasmic reticulum, promote hepatocyte regeneration, accelerate the repair of liver tissue, and restore liver function.

2. Improve the phagocytic function of liver Kupffer cells, prevent further damage to liver cells from intestinal toxins, inhibit the activity of tumor necrosis factor (TNF), thereby promoting the repair of liver necrosis.

Dosage: 2-3mg/ or iv for dogs and cats.

Ten, 3AA

Ingredients: Leucine, Isoleucine, Valine.

The three amino acids are branched-chain amino acids, and the side chains in the three molecular structures have branched amino acids.

1. Function:

(1) Valine, leucine, and isoleucine are branched-chain amino acids, which can correct the imbalance of branched-chain amino acids and aromatic amino acids in plasma after entering the body, and prevent hepatic coma caused by excessive concentration of aromatic amino acids in the brain.

(2) It can promote protein synthesis and reduce protein decomposition, which is beneficial to the regeneration and repair of liver cells, and can improve hypoalbuminemia.

(3) It is directly metabolized in muscle, fat, heart, brain and other tissues to generate energy for the body to use and reduce the burden on the liver.

2. Applicable to: Hepatic encephalopathy, severe hepatitis and liver cirrhosis, chronic active hepatitis caused by various reasons.

Dosage: 10ml/kg/d for dogs and cats.

Eleven, Yinzhihuang

1. Ingredient: Yin Chen, Gardenia, Astragalus, Honeysuckle Extract.

Yin Chen: It can promote bile secretion and excretion of bile acid and bilirubin in bile.

Gardenia: choleretic effect, can increase the secretion of bile, and can inhibit the increase of bilirubin in the blood.

Baicalin: It can be used for damp-heat jaundice and has a broad-spectrum antibacterial effect.

Honeysuckle: has broad-spectrum antibacterial and anti-influenza virus effects

2. It has the functions of clearing away heat, detoxification and dampness, and has the functions of jaundice and alanine aminotransferase reduction.

Applicable objects: Both dogs and cats can be used for acute, persistent, chronic hepatitis and severe hepatitis, and it can also be used for comprehensive treatment of other types of severe hepatitis.

3. Usage: Dilute with 250~500ml of 10% glucose injection and instill it.

Section 2 Liver Disease Prescription Foods

1. Royal liver prescription food

Decreasing copper levels and increasing zinc levels minimizes copper accumulation in hepatocytes and intracellular damage due to cholestasis.

·Restriction of sodium intake reduces portal hypertension to reduce extravascular fluid accumulation.

· Synergistic antioxidant complex slows liver cell degeneration.

·High-energy and highly-absorbable vegetable protein can reduce the burden on the liver and limit the occurrence or aggravation of liver disease.

Analysis and comparison of medication for liver disease in dogs and cats

2. Hills (L/D)

Appropriate content of easily digestible high-quality protein can help reduce the burden of liver function and maintain liver function.

The added L-carnitine helps maintain normal fat metabolism in the liver.

Added antioxidants, such as vitamins E and C, help control cellular oxidation and maintain a healthy immune system.

Low sodium helps maintain normal blood pressure.

Can be used for hepatitis, biliary liver disease, hepatic encephalopathy, fatty liver cases.

Contraindications: Hyperlipidemia, pregnancy.

Article source: Dr. Wang Lili, Ornamental Animal Hospital